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We studied nine patients with motor and phonic tics and other features of Tourette's syndrome,who developed persistent dystonia in addition to their tics.All,except one,were males(mean age 35.8 years;range,8 to 59 years), and had onset of tics prior to age 18 years(mean age,9 years;range,1.5 to 17 years).None of the patients were treated with neuroleptic drugs prior to the onset of dystonia.Torticollis and blepharospasm were the most common forms of dystonia.Seven patients had a history of tics in first degree relatives.While these patients were seen in a specialized movement disorder clinic and may,therefore,represent a population with atypical and more severe symptoms,the high prevalence rate of dystonia(5.0%of all patients with Tourette's syndrome seen in the clinic)suggests that some patients with tics may have an increased risk for dystonia. |
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